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If the patient’s CYP2C9 and/or coumadin VKORC1 genotype are known, consider these ranges in choosing the initial dose . Patients with CYP2C9 *1/*3, *2/*2, *2/*3, and *3/*3 may require more prolonged time ( > 2 to 4 weeks) to achieve maximum INR effect for a given dosage regimen than patients without these CYP coumadin and warfarin difference coumadin therapy coumadin what is it used for what does coumadin variants . Table 1 displays three ranges of expected maintenance COUMADIN doses observed in subgroups of patients having different combinations of CYP2C9 and VKORC1 coumadin gene variants [see CLINICAL PHARMACOLOGY] .
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